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Welcome to the Stem Cell Laboratory at Koc University!

Our lab studies the molecular mechanisms of cellular reprogramming. We want to understand how somatic cells such as skin fibroblasts can be converted into induced pluripotent stem cells (iPSC). Our focus is on identifying the role of chromatin modifying proteins in this process.

We are also interested in generating iPSCs from Turkish patients with rare genetic diseases for in vitro disease modeling and genome editing.

Genome editing of disease-specific induced pluripotent stem cells

Reprogramming has enabled the generation of patient-specific induced pluripotent stem (iPS) cells which can be used in disease modeling. However considerable clonal variability exists among different disease-specific iPSCs. One  way to overcome the variability among disease-specific iPSC lines, especially with respect to monogenic diseases, is to generate genetically defined sibling cell lines. Genome editing usingZinc […]

Welcome to the Stem Cell Laboratory at Koç University!

Our lab studies the molecular mechanisms of cellular reprogramming. We want to understand how somatic cells such  as skin fibroblasts can be converted into induced pluripotent stem cells (iPSC). Our focus is on identifying the role  of chromatin modifying proteins in this process. We are also interested in generating iPSCs from Turkish patients with rare genetic diseases for in vitro disease modeling and […]