Category archives for Research

Genome editing of disease-specific induced pluripotent stem cells

Reprogramming has enabled the generation of patient-specific induced pluripotent stem (iPS) cells which can be used in disease modeling. However considerable clonal variability exists among different disease-specific iPSCs. One  way to overcome the variability among disease-specific iPSC lines, especially with respect to monogenic diseases, is to generate genetically defined sibling cell lines. Genome editing usingZinc […]