Selected Publications
BRD9-containing non-canonical BAF complex maintains somatic cell transcriptome and acts as a barrier to human reprogramming Journal Article
In: Stem Cell Reports, vol. 17, no. 12, pp. 2629–2642, 2022.
Going up the hill: chromatin-based barriers to epigenetic reprogramming Journal Article
In: The FEBS Journal, vol. 288, no. 16, pp. 4798–4811, 2021.
Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming Journal Article
In: Nature chemical biology, vol. 15, no. 5, pp. 519–528, 2019.
Chromatin-modifying enzymes as modulators of reprogramming Journal Article
In: Nature, vol. 483, no. 7391, pp. 598–602, 2012.
All Publications
2022
EPIKOL, a chromatin-focused CRISPR/Cas9-based screening platform, to identify cancer-specific epigenetic vulnerabilities Journal Article
In: Cell Death & Disease, vol. 13, no. 8, pp. 710, 2022.
In: Nature cell biology, vol. 24, no. 4, pp. 554–564, 2022.
Perspectives on current models of Friedreich’s ataxia Journal Article
In: Frontiers in Cell and Developmental Biology, pp. 1588, 2022.
BRD9-containing non-canonical BAF complex maintains somatic cell transcriptome and acts as a barrier to human reprogramming Journal Article
In: Stem Cell Reports, vol. 17, no. 12, pp. 2629–2642, 2022.
2021
Going up the hill: chromatin-based barriers to epigenetic reprogramming Journal Article
In: The FEBS Journal, vol. 288, no. 16, pp. 4798–4811, 2021.
AF10 (MLLT10) prevents somatic cell reprogramming through regulation of DOT1L-mediated H3K79 methylation Journal Article
In: Epigenetics & Chromatin, vol. 14, no. 1, pp. 1–13, 2021.
In vivo library screening identifies the metabolic enzyme aldolase A as a promoter of metastatic lung colonization Journal Article
In: Iscience, vol. 24, no. 5, pp. 102425, 2021.
Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids Journal Article
In: Cell Stem Cell, vol. 28, no. 5, pp. 816–832, 2021.
Development, characterization, and hematopoietic differentiation of Griscelli syndrome type 2 induced pluripotent stem cells Journal Article
In: Stem cell research & therapy, vol. 12, no. 1, pp. 1–13, 2021.
In: Stem Cell Research, vol. 54, pp. 102438, 2021.
2020
NLRP7 plays a functional role in regulating BMP4 signaling during differentiation of patient-derived trophoblasts Journal Article
In: Cell Death & Disease, vol. 11, no. 8, pp. 658, 2020.
Systematic characterization of chromatin modifying enzymes identifies KDM3B as a critical regulator in castration resistant prostate cancer Journal Article
In: Oncogene, vol. 39, no. 10, pp. 2187–2201, 2020.
In: Biology of Reproduction, vol. 102, no. 6, pp. 1270–1280, 2020.
2019
Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming Journal Article
In: Nature chemical biology, vol. 15, no. 5, pp. 519–528, 2019.
Leptin treatment of in vitro cultured embryos increases outgrowth rate of inner cell mass during embryonic stem cell derivation Journal Article
In: In Vitro Cellular & Developmental Biology-Animal, vol. 55, pp. 473–481, 2019.
In: Molecular & Cellular Proteomics, vol. 18, no. 9, pp. 1756–1771, 2019.
Robust, long-term culture of endoderm-derived hepatic organoids for disease modeling Journal Article
In: Stem Cell Reports, vol. 13, no. 4, pp. 627–641, 2019.
2017
Inhibition and enhancement of reprogramming by chromatin modifying enzymes Miscellaneous
2017, (US Patent 9,670,463).
KDM2B, an H3K36-specific demethylase, regulates apoptotic response of GBM cells to TRAIL Journal Article
In: Cell Death & Disease, vol. 8, no. 6, pp. e2897–e2897, 2017.
In: Immunity, vol. 47, no. 1, pp. 183–198, 2017.
Epigenetic reprogramming of lineage-committed human mammary epithelial cells requires DNMT3A and loss of DOT1L Journal Article
In: Stem cell reports, vol. 9, no. 3, pp. 943–955, 2017.
2016
Transgene-free disease-specific iPSC generation from fibroblasts and peripheral blood mononuclear cells Journal Article
In: Patient-Specific Induced Pluripotent Stem Cell Models: Generation and Characterization, pp. 215–231, 2016.
LIN28 regulates stem cell metabolism and conversion to primed pluripotency Journal Article
In: Cell stem cell, vol. 19, no. 1, pp. 66–80, 2016.
Histon 3 metillenmesinin yeniden programlanmadaki etkisinin incelenmesi Journal Article
In: PhD, İstanbul Üniversitesi, İstanbul, Turkey (in Turkish), 2016.
2015
Generation of integration-free induced pluripotent stem cells from a patient with Familial Mediterranean Fever (FMF) Journal Article
In: Stem Cell Research, vol. 15, no. 3, pp. 694–696, 2015.
2014
Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cell identity Journal Article
In: Molecular cell, vol. 53, no. 1, pp. 32–48, 2014.
The epithelial-mesenchymal transition factor SNAIL paradoxically enhances reprogramming Journal Article
In: Stem cell reports, vol. 3, no. 5, pp. 691–698, 2014.
2013
Influence of threonine metabolism on S-adenosylmethionine and histone methylation Journal Article
In: Science, vol. 339, no. 6116, pp. 222–226, 2013.
Genome-wide chromatin state transitions associated with developmental and environmental cues Journal Article
In: Cell, vol. 152, no. 3, pp. 642–654, 2013.
Mechanisms of Somatic Cell Reprogramming Journal Article
In: Stem Cells: Current Challenges and New Directions, pp. 301–316, 2013.
2012
Chromatin-modifying enzymes as modulators of reprogramming Journal Article
In: Nature, vol. 483, no. 7391, pp. 598–602, 2012.
New lessons learned from disease modeling with induced pluripotent stem cells Journal Article
In: Current opinion in genetics & development, vol. 22, no. 5, pp. 500–508, 2012.
2011
Methods for identification and use of agents targeting cancer stem cells Patent
2011, (US Patent App. 12/937,070).
Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence Journal Article
In: Oncogene, vol. 30, no. 12, pp. 1489–1496, 2011.
Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity Journal Article
In: Nature cell biology, vol. 13, no. 10, pp. 1214–1223, 2011.
microRNAs become macro players in somatic cell reprogramming Journal Article
In: Genome Medicine, vol. 3, pp. 1–3, 2011.
Midbodies contribute to cellular reprogramming and tumorigenicity by evading autophagy. Proceedings Article
In: MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA 2011.
2010
In: Proceedings of the National Academy of Sciences, vol. 107, no. 35, pp. 15449–15454, 2010.
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells Journal Article
In: Nature genetics, vol. 42, no. 12, pp. 1113–1117, 2010.
Autocrine TGF-B and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts Journal Article
In: Proceedings of the National Academy of Sciences, vol. 107, no. 46, pp. 20009–20014, 2010.
miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis Journal Article
In: Nature cell biology, vol. 12, no. 3, pp. 247–256, 2010.
2009
Identification of selective inhibitors of cancer stem cells by high-throughput screening Journal Article
In: Cell, vol. 138, no. 4, pp. 645–659, 2009.
Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence Journal Article
In: Proceedings of the National Academy of Sciences, vol. 106, no. 1, pp. 169–174, 2009.
2008
Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways Journal Article
In: Cancer research, vol. 68, no. 10, pp. 3645–3654, 2008.
Role of E-cadherin in Tumor Metastasis and Discovery of Compounds Targeting Metastasis Cancer Cells PhD Thesis
Massachusetts Institute of Technology, Department of Biology, 2008.
2007
Adaptation versus selection: the origins of metastatic behavior Journal Article
In: Cancer research, vol. 67, no. 24, pp. 11476–11480, 2007.