Publications

Selected Publications

BRD9-containing non-canonical BAF complex maintains somatic cell transcriptome and acts as a barrier to human reprogramming

Sevinç, Kenan; Sevinç, Gülben Gürhan; Cavga, Ayşe Derya; Philpott, Martin; Kelekçi, Simge; Can, Hazal; Cribbs, Adam P; Yıldız, Abdullah Burak; Yılmaz, Alperen; Ayar, Enes Sefa; others,

BRD9-containing non-canonical BAF complex maintains somatic cell transcriptome and acts as a barrier to human reprogramming Journal Article

In: Stem Cell Reports, vol. 17, no. 12, pp. 2629–2642, 2022.

Links

Going up the hill: chromatin-based barriers to epigenetic reprogramming

Arabacı, Dilşad H; Terzioğlu, Gizem; Bayırbaşı, Büşra; Önder, Tamer T

Going up the hill: chromatin-based barriers to epigenetic reprogramming Journal Article

In: The FEBS Journal, vol. 288, no. 16, pp. 4798–4811, 2021.

Links

Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming

Ebrahimi, Ayyub; Sevinç, Kenan; Sevinç, Gülben Gürhan; Cribbs, Adam P; Philpott, Martin; Uyulur, Fırat; Morova, Tunç; Dunford, James E; Göklemez, Sencer; Arı, Şule; others,

Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming Journal Article

In: Nature chemical biology, vol. 15, no. 5, pp. 519–528, 2019.

Links

Chromatin-modifying enzymes as modulators of reprogramming

Onder, Tamer T; Kara, Nergis; Cherry, Anne; Sinha, Amit U; Zhu, Nan; Bernt, Kathrin M; Cahan, Patrick; Mancarci, B Ogan; Unternaehrer, Juli; Gupta, Piyush B; others,

Chromatin-modifying enzymes as modulators of reprogramming Journal Article

In: Nature, vol. 483, no. 7391, pp. 598–602, 2012.

Links

All Publications

2022

Yedier-Bayram, Ozlem; Gokbayrak, Bengul; Kayabolen, Alisan; Aksu, Ali Cenk; Cavga, Ayse Derya; Cingöz, Ahmet; Kala, Ezgi Yagmur; Karabiyik, Goktug; Günsay, Rauf; Esin, Beril; others,

EPIKOL, a chromatin-focused CRISPR/Cas9-based screening platform, to identify cancer-specific epigenetic vulnerabilities Journal Article

In: Cell Death & Disease, vol. 13, no. 8, pp. 710, 2022.

Links

Zhang, Yun; Donaher, Joana Liu; Das, Sunny; Li, Xin; Reinhardt, Ferenc; Krall, Jordan A; Lambert, Arthur W; Thiru, Prathapan; Keys, Heather R; Khan, Mehreen; others,

Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis Journal Article

In: Nature cell biology, vol. 24, no. 4, pp. 554–564, 2022.

Links

Kelekçi, Simge; Yıldız, Abdullah Burak; Sevinç, Kenan; Çimen, Deniz Uğurlu; Önder, Tamer

Perspectives on current models of Friedreich’s ataxia Journal Article

In: Frontiers in Cell and Developmental Biology, pp. 1588, 2022.

Links

Ozyerli-Goknar, Ezgi; Kala, Ezgi Yagmur; Aksu, Ali Cenk; Bulut, Ipek; Cingoz, Ahmet; Nizamuddin, Sheikh; Biniossek, Martin; Seker-Polat, Fidan; Morova, Tunc; Aztekin, Can; others,

Epigenetic-focused CRISPR/Cas9 screen identifies ASH2L as a regulator of glioblastoma cell survival Unpublished

2022.

Links

Sevinç, Kenan; Sevinç, Gülben Gürhan; Cavga, Ayşe Derya; Philpott, Martin; Kelekçi, Simge; Can, Hazal; Cribbs, Adam P; Yıldız, Abdullah Burak; Yılmaz, Alperen; Ayar, Enes Sefa; others,

BRD9-containing non-canonical BAF complex maintains somatic cell transcriptome and acts as a barrier to human reprogramming Journal Article

In: Stem Cell Reports, vol. 17, no. 12, pp. 2629–2642, 2022.

Links

2021

Arabacı, Dilşad H; Terzioğlu, Gizem; Bayırbaşı, Büşra; Önder, Tamer T

Going up the hill: chromatin-based barriers to epigenetic reprogramming Journal Article

In: The FEBS Journal, vol. 288, no. 16, pp. 4798–4811, 2021.

Links

Uğurlu-Çimen, Deniz; Odluyurt, Deniz; Sevinç, Kenan; Özkan-Küçük, Nazlı Ezgi; Özçimen, Burcu; Demirtaş, Deniz; Enüstün, Eray; Aztekin, Can; Philpott, Martin; Oppermann, Udo; others,

AF10 (MLLT10) prevents somatic cell reprogramming through regulation of DOT1L-mediated H3K79 methylation Journal Article

In: Epigenetics & Chromatin, vol. 14, no. 1, pp. 1–13, 2021.

Links

Tu, Zhenbo; Hou, Shengqi; Zheng, Yurong; Abuduli, Maerjianghan; Onder, Tamer; Intlekofer, Andrew M; Karnoub, Antoine E

In vivo library screening identifies the metabolic enzyme aldolase A as a promoter of metastatic lung colonization Journal Article

In: Iscience, vol. 24, no. 5, pp. 102425, 2021.

Links

Marsee, Ary; Roos, Floris JM; Verstegen, Monique MA; Roos, Floris; Verstegen, Monique; Clevers, Hans; Vallier, Ludovic; Takebe, Takanori; Huch, Meritxell; Peng, Weng Chuan; others,

Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids Journal Article

In: Cell Stem Cell, vol. 28, no. 5, pp. 816–832, 2021.

Links

Güney-Esken, Gülen; Erol, Özgür Doğuş; Pervin, Burcu; Sevinç, Gülben Gürhan; Önder, Tamer; Bilgiç, Elif; Korkusuz, Petek; Günel-Özcan, Ayşen; Uçkan-Çetinkaya, Duygu; Aerts-Kaya, Fatima

Development, characterization, and hematopoietic differentiation of Griscelli syndrome type 2 induced pluripotent stem cells Journal Article

In: Stem cell research & therapy, vol. 12, no. 1, pp. 1–13, 2021.

Links

Kelekçi, Simge; Uğurlu-Çimen, Deniz; Demir, Ata Berk; Özçimen, Burcu; Yıldız, Abdullah Burak; Karakuş, Mehmet Batuhan; Yücel, Esra Börklü; Önder, Tamer T

Generation of transgene-free iPSC lines from three patients with Friedreich’s ataxia (FRDA) carrying GAA triplet expansions in the first intron of FXN gene Journal Article

In: Stem Cell Research, vol. 54, pp. 102438, 2021.

Links

2020

Alici-Garipcan, Aybuke; Özçimen, Burcu; Süder, Ilke; Ülker, Volkan; Önder, Tamer T; Özören, Nesrin

NLRP7 plays a functional role in regulating BMP4 signaling during differentiation of patient-derived trophoblasts Journal Article

In: Cell Death & Disease, vol. 11, no. 8, pp. 658, 2020.

Links

Saraç, Hilal; Morova, Tunç; Pires, Elisabete; McCullagh, James; Kaplan, Anıl; Cingöz, Ahmet; Bagci-Onder, Tugba; Önder, Tamer; Kawamura, Akane; Lack, Nathan A

Systematic characterization of chromatin modifying enzymes identifies KDM3B as a critical regulator in castration resistant prostate cancer Journal Article

In: Oncogene, vol. 39, no. 10, pp. 2187–2201, 2020.

Links

Bildik, Gamze; Akin, Nazli; Esmaeilian, Yashar; Hela, Francesko; Yakin, Kayhan; Onder, Tamer; Urman, Bulent; Oktem, Ozgur

hCG improves luteal function and promotes progesterone output through the activation of JNK pathway in the luteal granulosa cells of the stimulated IVF cycles Journal Article

In: Biology of Reproduction, vol. 102, no. 6, pp. 1270–1280, 2020.

Links

2019

Ebrahimi, Ayyub; Sevinç, Kenan; Sevinç, Gülben Gürhan; Cribbs, Adam P; Philpott, Martin; Uyulur, Fırat; Morova, Tunç; Dunford, James E; Göklemez, Sencer; Arı, Şule; others,

Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming Journal Article

In: Nature chemical biology, vol. 15, no. 5, pp. 519–528, 2019.

Links

Taskin, Ali Cihan; Kocabay, Ahmet; Ebrahimi, Ayyub; Karahuseyinoglu, Sercin; Sahin, Gizem Nur; Ozcimen, Burcu; Ruacan, Arzu; Onder, Tamer T

Leptin treatment of in vitro cultured embryos increases outgrowth rate of inner cell mass during embryonic stem cell derivation Journal Article

In: In Vitro Cellular & Developmental Biology-Animal, vol. 55, pp. 473–481, 2019.

Links

Kagiali, Zeynep Cansu Uretmen; Sanal, Erdem; Karayel, Özge; Polat, Ayse Nur; Saatci, Özge; Ersan, Pelin Gülizar; Trappe, Kathrin; Renard, Bernhard Y; Önder, Tamer T; Tuncbag, Nurcan; others,

Systems-level Analysis Reveals Multiple Modulators of Epithelial-mesenchymal Transition and Identifies DNAJB4 and CD81 as Novel Metastasis Inducers in Breast Cancer*[S] Journal Article

In: Molecular & Cellular Proteomics, vol. 18, no. 9, pp. 1756–1771, 2019.

Links

Akbari, Soheil; Sevinç, Gülben Gürhan; Ersoy, Nevin; Basak, Onur; Kaplan, Kubra; Sevinc, Kenan; Ozel, Erkin; Sengun, Berke; Enustun, Eray; Ozcimen, Burcu; others,

Robust, long-term culture of endoderm-derived hepatic organoids for disease modeling Journal Article

In: Stem Cell Reports, vol. 13, no. 4, pp. 627–641, 2019.

Links

2017

Onder, Tamer T; Daley, George Q

Inhibition and enhancement of reprogramming by chromatin modifying enzymes Miscellaneous

2017, (US Patent 9,670,463).

Links

Kurt, Ibrahim Cagri; Sur, Ilknur; Kaya, Ezgi; Cingoz, Ahmet; Kazancioglu, Selena; Kahya, Zeynep; Toparlak, Omer Duhan; Senbabaoglu, Filiz; Kaya, Zeynep; Ozyerli, Ezgi; others,

KDM2B, an H3K36-specific demethylase, regulates apoptotic response of GBM cells to TRAIL Journal Article

In: Cell Death & Disease, vol. 8, no. 6, pp. e2897–e2897, 2017.

Links

Takata, Kazuyuki; Kozaki, Tatsuya; Lee, Christopher Zhe Wei; Thion, Morgane Sonia; Otsuka, Masayuki; Lim, Shawn; Utami, Kagistia Hana; Fidan, Kerem; Park, Dong Shin; Malleret, Benoit; others,

Induced-pluripotent-stem-cell-derived primitive macrophages provide a platform for modeling tissue-resident macrophage differentiation and function Journal Article

In: Immunity, vol. 47, no. 1, pp. 183–198, 2017.

Links

Breindel, Jerrica L; Skibinski, Adam; Sedic, Maja; Wronski-Campos, Ania; Zhou, Wenhui; Keller, Patricia J; Mills, Joslyn; Bradner, James; Onder, Tamer; Kuperwasser, Charlotte

Epigenetic reprogramming of lineage-committed human mammary epithelial cells requires DNMT3A and loss of DOT1L Journal Article

In: Stem cell reports, vol. 9, no. 3, pp. 943–955, 2017.

Links

2016

Fidan, Kerem; Ebrahimi, Ayyub; Çağlayan, Özlem H; Özçimen, Burcu; Önder, Tamer T

Transgene-free disease-specific iPSC generation from fibroblasts and peripheral blood mononuclear cells Journal Article

In: Patient-Specific Induced Pluripotent Stem Cell Models: Generation and Characterization, pp. 215–231, 2016.

Links

Zhang, Jin; Ratanasirintrawoot, Sutheera; Chandrasekaran, Sriram; Wu, Zhaoting; Ficarro, Scott B; Yu, Chunxiao; Ross, Christian A; Cacchiarelli, Davide; Xia, Qing; Seligson, Marc; others,

LIN28 regulates stem cell metabolism and conversion to primed pluripotency Journal Article

In: Cell stem cell, vol. 19, no. 1, pp. 66–80, 2016.

Links

Ebrahimi, Ayyub; Biyoloji, Moleküler; Şule, ARI; Danışman, II; ÖNDER, Tamer T

Histon 3 metillenmesinin yeniden programlanmadaki etkisinin incelenmesi Journal Article

In: PhD, İstanbul Üniversitesi, İstanbul, Turkey (in Turkish), 2016.

Links

2015

Fidan, Kerem; Kavaklıoğlu, Gülnihal; Ebrahimi, Ayyub; Özlü, Can; Ay, Nur Zeynep; Ruacan, Arzu; Gül, Ahmet; Önder, Tamer T

Generation of integration-free induced pluripotent stem cells from a patient with Familial Mediterranean Fever (FMF) Journal Article

In: Stem Cell Research, vol. 15, no. 3, pp. 694–696, 2015.

Links

2014

Das, Partha Pratim; Shao, Zhen; Beyaz, Semir; Apostolou, Eftychia; Pinello, Luca; Angeles, Alejandro De Los; O’Brien, Kassandra; Atsma, Jennifer Marino; Fujiwara, Yuko; Nguyen, Minh; others,

Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cell identity Journal Article

In: Molecular cell, vol. 53, no. 1, pp. 32–48, 2014.

Links

Unternaehrer, Juli J; Zhao, Rui; Kim, Kitai; Cesana, Marcella; Powers, John T; Ratanasirintrawoot, Sutheera; Onder, Tamer; Shibue, Tsukasa; Weinberg, Robert A; Daley, George Q

The epithelial-mesenchymal transition factor SNAIL paradoxically enhances reprogramming Journal Article

In: Stem cell reports, vol. 3, no. 5, pp. 691–698, 2014.

Links

Gupta, Piyush; Onder, Tamer T; Lander, Eric S; Weinberg, Robert; Mani, Sendurai

PREDICTION AND FOLLOW-UP OF THE RESPONSE TO ANTICANCER THERAPY BASED ON THE PROFILING OF GENE EXPRESSION Patent

2014.

Links

2013

Shyh-Chang, Ng; Locasale, Jason W; Lyssiotis, Costas A; Zheng, Yuxiang; Teo, Ren Yi; Ratanasirintrawoot, Sutheera; Zhang, Jin; Onder, Tamer; Unternaehrer, Juli J; Zhu, Hao; others,

Influence of threonine metabolism on S-adenosylmethionine and histone methylation Journal Article

In: Science, vol. 339, no. 6116, pp. 222–226, 2013.

Links

Zhu, Jiang; Adli, Mazhar; Zou, James Y; Verstappen, Griet; Coyne, Michael; Zhang, Xiaolan; Durham, Timothy; Miri, Mohammad; Deshpande, Vikram; Jager, Philip L De; others,

Genome-wide chromatin state transitions associated with developmental and environmental cues Journal Article

In: Cell, vol. 152, no. 3, pp. 642–654, 2013.

Links

Onder, Tamer T

Mechanisms of Somatic Cell Reprogramming Journal Article

In: Stem Cells: Current Challenges and New Directions, pp. 301–316, 2013.

Links

2012

Onder, Tamer T; Kara, Nergis; Cherry, Anne; Sinha, Amit U; Zhu, Nan; Bernt, Kathrin M; Cahan, Patrick; Mancarci, B Ogan; Unternaehrer, Juli; Gupta, Piyush B; others,

Chromatin-modifying enzymes as modulators of reprogramming Journal Article

In: Nature, vol. 483, no. 7391, pp. 598–602, 2012.

Links

Onder, Tamer T; Daley, George Q

New lessons learned from disease modeling with induced pluripotent stem cells Journal Article

In: Current opinion in genetics & development, vol. 22, no. 5, pp. 500–508, 2012.

Links

Gupta, Plyush; Onder, Tamer T; Lander, Eric S; Weinberg, Robert; Mani, Sendurai

Prediction of and monitoring cancer therapy response based on gene expression profiling Patent

2012.

Links

2011

Gupta, Piyush; Onder, Tamer T; Lander, Eric S; Weinberg, Robert; Mani, Sendurai; Liao, Mai-Jing

Methods for identification and use of agents targeting cancer stem cells Patent

2011, (US Patent App. 12/937,070).

Links

Rai, Priyamvada; Young, Jennifer J; Burton, Dominick GA; Giribaldi, Maria G; Onder, Tamer T; Weinberg, Robert A

Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence Journal Article

In: Oncogene, vol. 30, no. 12, pp. 1489–1496, 2011.

Links

Kuo, Tse-Chun; Chen, Chun-Ting; Baron, Desiree; Onder, Tamer T; Loewer, Sabine; Almeida, Sandra; Weismann, Cara M; Xu, Ping; Houghton, Jean-Marie; Gao, Fen-Biao; others,

Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity Journal Article

In: Nature cell biology, vol. 13, no. 10, pp. 1214–1223, 2011.

Links

Onder, Tamer T; Daley, George Q

microRNAs become macro players in somatic cell reprogramming Journal Article

In: Genome Medicine, vol. 3, pp. 1–3, 2011.

Links

Kuo, TC; Chen, CT; Baron, D; Onder, TT; Loewer, S; Weismann, CM; Daley, GQ; Doxsey, S

Midbodies contribute to cellular reprogramming and tumorigenicity by evading autophagy. Proceedings Article

In: MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA 2011.

Links

2010

Taube, Joseph H; Herschkowitz, Jason I; Komurov, Kakajan; Zhou, Alicia Y; Gupta, Supriya; Yang, Jing; Hartwell, Kimberly; Onder, Tamer T; Gupta, Piyush B; Evans, Kurt W; others,

Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes Journal Article

In: Proceedings of the National Academy of Sciences, vol. 107, no. 35, pp. 15449–15454, 2010.

Links

Loewer, Sabine; Cabili, Moran N; Guttman, Mitchell; Loh, Yuin-Han; Thomas, Kelly; Park, In Hyun; Garber, Manuel; Curran, Matthew; Onder, Tamer; Agarwal, Suneet; others,

Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells Journal Article

In: Nature genetics, vol. 42, no. 12, pp. 1113–1117, 2010.

Links

Kojima, Yasushi; Acar, Ahmet; Eaton, Elinor Ng; Mellody, Kieran T; Scheel, Christina; Ben-Porath, Ittai; Onder, Tamer T; Wang, Zhigang C; Richardson, Andrea L; Weinberg, Robert A; others,

Autocrine TGF-B and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts Journal Article

In: Proceedings of the National Academy of Sciences, vol. 107, no. 46, pp. 20009–20014, 2010.

Links

Ma, Li; Young, Jennifer; Prabhala, Harsha; Pan, Elizabeth; Mestdagh, Pieter; Muth, Daniel; Teruya-Feldstein, Julie; Reinhardt, Ferenc; Onder, Tamer T; Valastyan, Scott; others,

miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis Journal Article

In: Nature cell biology, vol. 12, no. 3, pp. 247–256, 2010.

Links

2009

Gupta, Piyush B; Onder, Tamer T; Jiang, Guozhi; Tao, Kai; Kuperwasser, Charlotte; Weinberg, Robert A; Lander, Eric S

Identification of selective inhibitors of cancer stem cells by high-throughput screening Journal Article

In: Cell, vol. 138, no. 4, pp. 645–659, 2009.

Links

Rai, Priyamvada; Onder, Tamer T; Young, Jennifer J; McFaline, Jose L; Pang, Bo; Dedon, Peter C; Weinberg, Robert A

Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence Journal Article

In: Proceedings of the National Academy of Sciences, vol. 106, no. 1, pp. 169–174, 2009.

Links

2008

Onder, Tamer T; Gupta, Piyush B; Mani, Sendurai A; Yang, Jing; Lander, Eric S; Weinberg, Robert A

Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways Journal Article

In: Cancer research, vol. 68, no. 10, pp. 3645–3654, 2008.

Links

Onder, Tamer T

Role of E-cadherin in Tumor Metastasis and Discovery of Compounds Targeting Metastasis Cancer Cells PhD Thesis

Massachusetts Institute of Technology, Department of Biology, 2008.

Links

2007

Scheel, Christina; Onder, Tamer; Karnoub, Antoine; Weinberg, Robert A

Adaptation versus selection: the origins of metastatic behavior Journal Article

In: Cancer research, vol. 67, no. 24, pp. 11476–11480, 2007.

Links